Improving glioma resection with 2D-intraoperative ultrasound: Observational results and systematic literature correlation
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Maximizing tumor resection is a key prognostic factor in glioma surgery. Intraoperative cerebral ultrasonography (IOUS) offers real-time, cost-effective guidance that can enhance the extent of resection (EOR) and gross total resection (GTR) rates, but data remain heterogeneous. Methods: We conducted a retrospective analysis of a prospective observational database including patients with gliomas undergoing surgery with or without IOUS guidance in one tertiary neurosurgical center. Inclusion criteria were preoperative magnetic resonance imaging-suspected gliomas, intended GTR, and available early postoperative imaging. Outcomes were compared using propensity score matching. In addition, a systematic literature review covering 2018-2024 was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: . A learning curve effect was observed, with increasing resection rates over time. The literature review identified nine relevant studies, with GTR rates ranging from 42% to 91%, and recent studies showing improved outcomes with advanced IOUS techniques. These findings should be interpreted cautiously given the small sample size and single-center design. Conclusion: IOUS significantly enhances resection outcomes in glioma surgery and demonstrates a progressive benefit with surgeon experience. Given its versatility, low cost, and growing integration with technologies such as contrast-enhanced ultrasound and artificial intelligence, IOUS remains a fundamental tool in modern neurooncology. Future multicenter prospective studies are needed to standardize its use and assess long-term patient outcomes.
Source: Surgical Neurology International
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4416776216