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Successful treatment of 40-year chronic auricular cutaneous infection caused by multidrug-resistant Fusarium proliferatum via 5-aminolevulinic acid photodynamic therapy: A case report

Year: 2025

Type: article

Abstract: ABSTRACT We report the case of a 66-year-old woman with a 40-year history of a chronic Fusarium proliferatum infection on the right auricle. In vitro susceptibility testing showed resistance to common antifungals, including voriconazole and amphotericin B. Following the failure of conventional antifungal therapies, 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) was initiated as monotherapy. The patient underwent 10 treatment sessions, with the ALA concentration and light parameters adjusted based on the auricle's anatomy. Post-treatment follow-up demonstrated complete resolution of the lesions, with no recurrence or scar formation observed. This case highlights the efficacy and safety of ALA-PDT for multidrug-resistant Fusarium proliferatum infections in specific anatomical sites, providing a valuable alternative for clinical management of refractory superficial fungal infections.

Source: Medical Mycology Case Reports

DOI: 10.1016/j.mmcr.2025.100755

Authors: Huiyu Zhang, Yahui Feng, Yiping Liang, Sisi Wang, Dongmei Shi

Institutions: Shandong University of Traditional Chinese Medicine, Jining First People's Hospital, Jining Medical University

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650