Work

COVID-19 vaccine-induced parkinsonism due to LGI1 antibody encephalitis: case report and brief literature review

Year: 2025

Type: article

Abstract: Anti-LGI1 encephalitis is an autoimmune disorder of the brain, characterized by subacute cognitive impairment, faciobrachial dystonic seizures, and hyponatremia. Although rare, recent reports suggest that LGI1 encephalitis may be triggered following COVID-19 exposure whether through infection or vaccination. It usually presents with insidious progression which, along with old age predominance, may delay the diagnosis. We herein report a 67-year-old patient with positive LGI1 antibody titers, who developed subacute parkinsonism after serial COVID-19 vaccination. To our knowledge, this is the first documented case report highlighting a potential association between COVID-19 vaccination and the development of parkinsonism in the context of LGI1 encephalitis.

Source: Oxford Medical Case Reports

DOI: 10.1093/omcr/omaf236

Authors: Abdalla Khabazeh, Jetish Kumar, Volney Sheen

Institutions: Damascus University, Beth Israel Deaconess Medical Center, Harvard University

Language: English

Topic: Autoimmune Neurological Disorders and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,103