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Fourier Transform Near-Infrared Spectrometry Reveals Significant Inter-Lot Variability in Thyrotropin Alfa (Thyrogen®) Quality

Year: 2025

Type: article

Abstract: . Only one vial was an outlier, appearing 7.8 SDs away from the center of the library spectral cluster. Some literature suggests differences in the spectra of vials may reflect differences in the stability and efficacy of the drug.

Source: PubMed

DOI: 10.6084/m9.figshare.30403540

Authors: Lodder, Robert, Yoon, Uiyeol, Almeter, Philip, Hasani, Eleonora, Hunter, Aaron, Lyman, Thomas, Zapata, Stephanie, Henderson, Bradley, Larkin, Seth, Crumrin, Adler, Smith, Jerod, Pergrem, Spencer, Plymale, Ashton, Ramnes, Bailee, Knight, Reagan, Vongchan, Erin, Schnabel, Samantha, Hall, Bailey, Sharp, Kyra, Geib, Madison, Wingate, Abby, W. Naseman, Ryan

Institutions: University of Kentucky HealthCare, University of Kentucky

Language: English

Topic: Spectroscopy and Chemometric Analyses

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Center for Advancing Translational Sciences

Award: Kentucky Center for Clinical and Translational Science

OpenAlex ID: W4416786812

FWCI:

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