Cam morphology and the risk of developing radiographic hip osteoarthritis within 8 years: an individual participant data meta-analysis of 23 886 hips from the world COACH consortium
Year: 2025
Type: review
Abstract: OBJECTIVE: To assess the relationship between cam morphology and the development of radiographic hip osteoarthritis (RHOA), overall and in subgroups based on age, biological sex and body mass index (BMI). METHODS: used to define cam morphology. Incident RHOA was defined as the transition from an RHOA-free state at baseline to definite diagnosis of RHOA at follow-up. The association between baseline cam morphology and the development of RHOA was assessed using a three-level mixed-effects logistic regression model, accounting for hip side, individual and cohort-level variation. RESULTS: A total of 23 886 hips were included (mean age: 62.2±8.4 years; 70.6% female; BMI: 27.4±4.5; mean time to follow-up: 6.1±3.0 years). Cam morphology was associated with RHOA (OR: 1.87, 95% CI 1.36 to 2.59), as was a greater alpha angle (OR 1.02, 95% CI 1.01 to 1.03 for every degree increase). The overall relative risk of developing RHOA in hips with cam morphology was 1.62 (95%CI 1.26 to 2.07), greatest for those aged 51-60 years (2.15, 95% CI 1.55 to 2.98) and higher in males (2.50, 95% CI 1.67 to 3.73), compared with females (1.75,95% CI 1.24 to 2.48). CONCLUSION: Hips with cam morphology have higher odds of developing RHOA within 4-8 years compared with hips without cam morphology. The relative risk was highest in subgroups of participants aged 51-60 years and in males, making cam morphology a potential target for primary or secondary prevention of RHOA.
Authors: Jinchi Tang, Fleur Boel, Michiel MA van Buuren, Noortje S Riedstra, Myrthe A van den Berg, Harbeer Ahedi, Nigel K Arden, Sita M A Bierma-Zeinstra, Cindy G Boer, Flavia Cicutini, Timothy Cootes, Kay M Crossley, David T Felson, Willem-Paul Gielis, Joshua J Heerey, Graeme Jones, Stefan Kluzek, Nancy E Lane, Claudia Lindner, John A Lynch, Joyce van Meurs, Andrea Britt Mosler, Amanda E Nelson, Michael Nevitt, Edwin H G Oei, Jos Runhaar, Harrie Weinans, Rintje Agricola
Institutions: Erasmus MC, The University of Sydney, University of Tasmania, University of Oxford, Monash University, University of Manchester, La Trobe University, Boston University, University Medical Center Utrecht, University of Nottingham, University of California, Davis, University of California, San Francisco, Delft University of Technology
Language: English
Topic: Hip disorders and treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: Boston University, Wellcome Trust, Royal Society, China Scholarship Council, National Institutes of Health, Centers for Disease Control and Prevention, University of California, San Francisco, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: Study of Osteoporotic Fractures, Developing a software system to improve the management and outcome of knee replacement surgery by combining radiographic image information with clinical and patient data, G2060701114, G2091924775, Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical Center, JOHNSTON COUNTY OSTEOARTHRITIS PROJECT: ARTHRITIS, DISABILITY, AND OTHER CHRONIC DISEASES, THE JOHNSTON COUNTY OA PROJECT: ARTHRITIS AND DISABILITY, G3049869442, G3723061141, G409491633, Study of Osteoporotic Fractures, G430788307, Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical Center, Study of Osteoporotic Fractures, Study of Osteoporotic Fractures (SOF)-Pittsburgh Clinic, Multicenter Osteoarthritis Study (MOST) Second Renewal, NIAMS Multidisciplinary Clinical Research Center, G551515871, G604760239, G6311601004, G6355893076, G659721583, NIAMS Multidisciplinary Clin Res Ctr: Rheumatic Diseases, Study of Osteoporotic Fractures, G76550502, G769444117, MULTIPURPOSE ARTHRITIS &MUSCULOSKELETAL DISEASES CENTER, Developing a software system to improve the management and outcome of knee replacement surgery by combining radiographic image information with clinical and patient data, Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston University, G8835503869, G897039181, UNC Core Center for Clinical Research
OpenAlex ID: W4416788826