Work

Rapid treatment of depression with potassium supplementation: relative deficiency of potassium ions and possible pathogenesis—a case report

Year: 2025

Type: article

Abstract: BACKGROUND: Despite advances in depression research and treatment, effective strategies based on clear neural mechanisms are still lacking. Current therapies often show delayed effects and inconsistent outcomes, suggesting that the core pathophysiology remains unclear. CASE PRESENTATION: This case report describes a highly successful and rapid resolution of subacute mild anxiety and severe depression in a 32-year-old woman of Chinese origin following treatment with potassium ion supplementation. It explores the potential mechanisms underlying this therapeutic effect, highlighting the role of relative potassium ion deficiency in the pathogenesis of depression. CONCLUSION: This case achieved significant therapeutic outcomes through innovative treatment strategies, raising an interesting possibility on the pathogenesis of depression. However, more clinical observations or cohort studies are needed to support this finding.

Source: Journal of Medical Case Reports

DOI: 10.1186/s13256-025-05693-2

Author: Jiapei Dai

Institution: South Central Minzu University

Language: English

Topic: Treatment of Major Depression

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890