Urinary dopamine, sodium handling, and blood pressure in a bi-ethnic South African population: the SABPA study
Year: 2025
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Urinary dopamine is associated with increased sodium excretion in experimental studies, and possibly contributes to blood pressure (BP) regulation and salts-ensitivity. Studies in humans are limited, and the potential association with potassium is unclear. We aimed to compare urinary dopamine/creatinine ratio and investigate the associations of urinary dopamine/creatinine ratio with BP, sodium, potassium, and sodium/potassium ratio (Na/K) in Black and White adults. METHODS: We included Black (n = 160) and White (n = 197) men and women aged 20-65 years. We recorded 24-hour BP, measured urinary dopamine and creatinine, and calculated their ratio. Urinary sodium and potassium were measured, and Na/K ratio calculated. RESULTS: Urinary dopamine/creatinine ratio was lower in the Black group (p = 0.030) as compared to the White group, while urinary dopamine metabolites were higher in the Black group (p ≤ 0.001) compared to the White group. In multiple regression analyses, the following significant associations were confirmed: urinary dopamine/creatinine ratio associated positively with sodium and potassium in both the Black and White groups (all ß ≥ 0.296; p < 0.001) and negatively with Na/K ratio (ß = -0.285; p < 0.001) only in the Black group. No associations were observed between urinary dopamine/creatinine ratio and BP. CONCLUSION: ratio only in the Black participants suggest that potassium may contribute significantly to the renal sodium-handling properties of renal dopamine in Black populations.
Institutions: University of Johannesburg, North-West University
Language: English
Topic: Sodium Intake and Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4416788844
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