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Identification of mono-ADP-ribose readers using well-defined photoaffinity-based probes

Year: 2025

Type: article

Abstract: This study introduces new photoaffinity-based probes to identify mono-ADP-ribose readers. Using human cell extracts, it detects both known and potential readers, thereby improving our understanding of mono-ADP-ribosylation.

Source: RSC Chemical Biology

DOI: 10.1039/d5cb00176e

Authors: Femke L. A. M. van der Heijden, Suzanne A. Weijers, Spyridoula Kondyli, Onno Bleijerveld, Michiel Vermeulen, Dmitri V. Filippov

Institutions: Leiden University, Radboud University Nijmegen, The Netherlands Cancer Institute, Radboud Institute for Molecular Life Sciences

Language: English

Topic: Calcium signaling and nucleotide metabolism

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,962

Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek, KWF Kankerbestrijding, Oncode Institute, Exacte en Natuurwetenschappen

Awards: Synthetic affinity-based probes for proteome-wide identification of poly(ADP-ribosyl)-binding proteins, G7604097849

OpenAlex ID: W4416792028

FWCI: 0.555

Cites: 34

Cited by: 1

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