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Individualized Treosulfan-Based Conditioning Improves Outcomes of Allogeneic Hematopoietic Transplantation for Myelodysplastic Syndrome: A 25-Year Retrospective, Population-Based Analysis

Year: 2025

Type: article

Study design: Observational Study

Abstract: • Allo-HCT conditioning in MDS shifts toward reduced toxicity and broader eligibility • FluTreo have improved survival by lowering NRM without increasing relapse • Treosulfan dose-adjustment appears to mitigate comorbidity-related risk

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.jtct.2025.11.030

Authors: Johanne Skovgaard Schovsbo, Eileen Donohue Wedge, Henrik Sengeløv, Brian Thomas Kornblit, Ida Schjødt, Marietta Nygaard, Søren Lykke Petersen, Niels Smedegaard Andersen, Bo Kok Mortensen, Duruta Weber, Morten Orebo Holmström, Kirsten Grønbæk, Lone Smidstrup Friis

Institutions: Copenhagen University Hospital, Rigshospitalet, Odense University Hospital, Herlev Hospital

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650

Funders: Gilead Sciences, Rigshospitalet

OpenAlex ID: W4416795692

FWCI:

Cites: 5

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