Immune and viral surveillance of HIV-1C reservoirs in an Indian cohort
Year: 2025
Type: article
Study design: Observational Study
Abstract: displayed distinct neutralization profiles against best-in-class broadly neutralizing antibodies, highlighting the need for a combinatorial approach to target potential breakthrough viruses. Surveillance of the archival repertoire demonstrated the occurrence of drug resistance conferring mutations (>10%) across therapy states, including instances of primary and acquired resistance to recently introduced integrase strand transfer inhibitors. Our data, underlines the need for incorporating reservoir diversity in intervention and management strategies.
Source: iScience
Authors: Snehal Kaginkar, Shilpa Bhowmick, Nandini Kasarpalkar, Sharad Bhagat, Jyoti Sutar, Sapna Yadav, Sameen Khan, Pranay Gurav, Nandan Mohite, Namrata Neman, Nidhi Sehgal, Satyajit Musale, Varsha Padwal, Pratik Devadiga, Ranajoy Mullick, Priyanka Jayal, Tejaswini Pandey, Amit Kumar Singh, Shilpa Velhal, Sayantani Ghosh, Ritam Chatterjee, Varsha Kalsulkar, Vikrant Bhor, Gita Nataraj, Kavita Joshi, Nayana Ingole, Sachee Agrawal, Jayanthi Shastri, Sushma Gaikwad, Vidya Nagar, Priya Patil, Jayanta Bhattacharya, Vainav Patel
Institutions: National Institute for Research in Reproductive Health, Indian Council of Medical Research, International AIDS Vaccine Initiative, Narsee Monjee Institute of Management Studies, Shri Vile Parle Kelavani Mandal, King Edward Memorial Hospital and Seth G.S. Medical College, Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,240
Funders: International AIDS Vaccine Initiative, Wellcome Trust, Oxford Nanopore Technologies, Lady Tata Memorial Trust, Broad Institute, Department of Biotechnology, Ministry of Science and Technology, India, Department of Science and Technology, Ministry of Science and Technology, India, Indian Council of Medical Research, University Grants Commission, Ministry of Health and Family Welfare, The Wellcome Trust DBT India Alliance, Stanford Bio-X, Defence Science and Technology Group, National AIDS Control Organisation, Los Alamos National Laboratory
OpenAlex ID: W4416795771