Work

Fahr’s syndrome: Evaluation of bilateral basal ganglia and calcifications in other brain regions: A report of 3 cases

Year: 2025

Type: article

Abstract: Fahr's syndrome is a rare neurological disorder characterized by abnormal intracranial calcifications, most commonly affecting the basal ganglia. We report 3 cases-2 females aged 71 and 72, and 1 male aged 47-who were incidentally found to have bilateral basal ganglia calcifications on brain CT-scans. The first patient had a history of total thyroidectomy and parathyroidectomy; the second had prior psychiatric illness and was evaluated after a motor vehicle accident; the third was undergoing chemotherapy for hepatocellular carcinoma and presented with generalized weakness. Stroke was excluded in all cases, and each patient was discharged in stable condition. These cases highlight the importance of neuroimaging in identifying Fahr's syndrome, especially in atypical presentations, and underscore the need for thorough metabolic and clinical evaluation to guide diagnosis and management.

Source: Radiology Case Reports

DOI: 10.1016/j.radcr.2025.10.090

Authors: Soheil Mirzaei, Zahra Motaghed, Sara Arab Baferani, Reza Naseri, Farzin Lotfi

Institutions: Tarbiat Modares University, Shahid Beheshti University of Medical Sciences, Shahid Beheshti University

Language: English

Topic: Neurological and metabolic disorders

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600