Work

Post‐operative recovery of quality‐of‐life following percutaneous nephrolithotomy: The impact on pain intensity and interference and the ability to participate in social roles

Year: 2025

Type: article

Abstract: Objectives: To prospectively capture patient-reported outcomes in the post-operative period to better understand the quality-of-life impact of percutaneous nephrolithotomy (PNL). Subjects and Methods: Adults undergoing PNL for renal/ureteral stones were eligible for inclusion (11/2020-8/2022). Patients prospectively completed PROMIS - Pain Intensity, Pain Interference and Ability to participate in social roles and activities in-person pre-operatively (POD 0) and via email on POD 1, 7, 14 and 30. Scores are reported as T-scores (normalized to US pop., mean = 50) with a change of 5 (0.5 SD) considered clinically significant. Results: A total of 62 participants enrolled at POD 0 (POD 1 = 28, POD 7 = 29, POD 14 = 20, POD 30 = 23). There was a worsening of quality of life from POD 0 to POD 1 for pain intensity (median difference 7.9, p = 0.005) and pain interference (median difference 11.9, p = 0.0003), but not for the ability to participate in social roles (median difference -5.3, p = 0.07). This was also observed for POD 0 to POD 7, but only for the dimension of pain interference (median difference 7.2, p = 0.02). All three dimensions then improved until POD 30. In multivariable analysis, there were no variables associated with severe symptomatology for any of the three dimensions. Conclusions: Pain intensity and interference sharply increase immediately post-operatively, reducing quality of life, although the ability to participate in social roles is not impacted. The absolute magnitude of this change is significant, with a final improvement at 30 days at or above baseline. Results offer meaningful insight to assist in setting expectations for patients post-operatively.

Source: BJUI Compass

DOI: 10.1002/bco2.70102

Authors: Justin B. Ziemba, Amanda Jones, Hanna Stambakio, Gregory E. Tasian, Jing Huang

Institutions: Hospital of the University of Pennsylvania, University of Pennsylvania, Children's Hospital of Philadelphia

Language: English

Topic: Kidney Stones and Urolithiasis Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,770