Work

Unraveling the role of mitochondrial unfolded protein response in colorectal cancer

Year: 2025

Type: article

Abstract: Colorectal cancer (CRC) ranks among the most prevalent malignancies globally and is the third leading cause of cancer - related deaths. Despite advancements in diagnosis and treatment, prognosis for CRC patients, especially those with advanced or metastatic disease, remains difficult due to its heterogeneity. Mitochondria, central to cellular activity, and the mitochondrial unfolded protein response (UPR mt ), a stress - responsive pathway, are involved in various physiological and pathological processes. Recent studies have emphasized the importance of UPR mt in cancer biology. In this research, we explored the role of UPR - related genes (MRGs) in CRC. Through analyzing transcriptional profiles and clinical data of CRC patients, we identified different molecular subtypes according to MRG expression, which were related to patient prognosis, immune cell infiltration, and drug sensitivity. We also developed a prognostic signature based on key MRGs with strong predictive power for patient survival and treatment response. Additionally, the study of the spatial distribution of MRGs in tumor tissues revealed their heterogeneous expression and potential influence on tumor biology. Overall, our findings clarify the role of UPR in CRC and highlight its potential as a target for personalized cancer therapy. • Mitochondrial function and UPRmt are crucial in cancer biology and influence diverse physiological and pathological processes. UPRmt-related gene expression defines molecular subtypes linked to prognosis, immune infiltration, and drug sensitivity. • A prognostic signature based on key UPRmt-related genes robustly predicts patient survival and treatment response.

Source: Biochemistry and Biophysics Reports

DOI: 10.1016/j.bbrep.2025.102359

Authors: Jihao Shi, Lexi Wu, Chuwen Tian, Haotian Chen

Institutions: Sir Run Run Shaw Hospital, Zhejiang University

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,700