Work

Urinary tract infections due to Globicatella spp. in pediatric patients with complex uropathies

Year: 2025

Type: article

Abstract: • This is the most extensive study of Globicatella spp. UTI in pediatric patients. • Almost all patients had complex uropathies or congenital urinary tract malformations. • Globicatella spp. are frequently more susceptible to penicillin than to ceftriaxone. Globicatella is a genus of catalase-negative, facultative anaerobes, and non-hemolytic Gram-positive cocci, arranged in pairs or in short chains. Twenty-five positive urine cultures, mainly obtained by catheterization, and two urinary stone cultures due to Globicatella spp. were retrospectively recorded from patients between January 1, 2014 and October 31, 2024. Isolates were identified by mass spectrometry (Vitek MS), 16S rRNA gene sequencing and biochemical tests. Most patients had complex uropathies or congenital malformations of the urinary tract. A high percentage of the isolates showed high ceftriaxone (CRO) MICs (MIC50 and MIC90: 2–16 μg/ml) and almost half of them had low penicillin (PEN) MICs (MIC50 and MIC90: 0.25 and 2 μg/ml). The present study is the most extensive report of Globicatella urinary tract infections in children. Globicatella es un género de cocos gram positivos dispuestos en pares o en cadenas cortas, catalasa negativos, anaerobios facultativos y no hemolíticos. Se registraron retrospectivamente 25 urocultivos positivos, obtenidos principalmente por cateterismo, y dos cultivos de cálculos urinarios por Globicatella spp. de 26 pacientes entre el 1 de enero de 2014 y el 31 de octubre de 2024. Los aislamientos se identificaron mediante espectrometría de masas (Vitek MS), secuenciación del gen 16S ARNr y pruebas bioquímicas. La mayoría de los pacientes presentaban uropatías complejas o malformaciones congénitas del tracto urinario. Un alto porcentaje de los aislamientos presentó CIM más elevadas para ceftriaxona (CRO) (CIM50 y CIM90: 2 y 16 μg/ml) y casi la mitad de aquellos mostraron CIM bajas para penicilina (PEN) (CIM50 y CIM90: 0,25 y 2 μg/ml). Esta es la serie más extensa de infecciones del tracto urinario debidas a Globicatella en niños.

Source: Revista Argentina de Microbiología

DOI: 10.1016/j.ram.2025.10.007

Authors: Elena Berardinelli, Agustina Mancini, María Elena Venuta, Marcelo Darío Golemba, Horacio Lopardo

Institution: Garrahan Hospital

Language: English

Topic: Urinary Tract Infections Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200