Work

Allylation of C(sp 3 )─H Bonds Using a MW/Persulfate Protocol

Year: 2025

Type: article

Abstract: ABSTRACT The C(sp 3 )─H allylation reaction using allyl phenyl sulfone was affected by persulfate anion (PS) under microwave (MW) irradiation. The MW/PS protocol has been found to be applicable to a wide variety of C(sp 3 )─H bonds of ethers, alkanes, aldehydes, and ketones, leading to the C(sp 3 )─H allylated compounds. The origin of the site‐selectivity in the allylation of cyclohexanone is discussed in terms of the polarity‐governed transition states for the radical cascades involving hydrogen atom transfer (HAT), radical addition, and β‐elimination.

Source: Helvetica Chimica Acta

DOI: 10.1002/hlca.202500191

Authors: Hsin‐Hsuan Lee, Chun‐Yu Chen, Yen‐Ku Wu, Ilhyong Ryu

Institutions: National Yang Ming Chiao Tung University, Osaka Metropolitan University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,030

Funders: National Science and Technology Council, National Science and Technology Council, Japan Society for the Promotion of Science