Fucose dependent rotavirus and norovirus require fucosidase activity for optimal replication

Year: 2025

Type: article

Abstract: Rotavirus (RV) and norovirus (NoV) are enteric viruses responsible for acute gastroenteritis that require fucosylated histo-blood group antigens for infection in humans. How the interaction of these viruses with fucosylated glycans modulates infection is not well understood. Treatment of target cells with a bacterial α1,2 fucosidase enzyme reduced RV and NoV infection in vitro, but increased replication in vivo. Conversely, the fucosidase inhibitor 1-deoxyfuconojirimycin impaired viral replication in both models, highlighting the role of fucosidase activity in fucose-dependent enteric virus infection. This underscores the complexity of fucose interactions for these viruses and implicates fucosidase activity as a potential antiviral target for RV and NoV.

Source: npj Viruses

DOI: 10.1038/s44298-025-00164-3

Authors: Nazaret Peña-Gil, Nanci Santos-Ferreira, Sonia Llanos-Villatoro, Ana Melero, Roberto Cárcamo-Calvo, Sergi López-Navarro, Cristina Santiso-Bellón, Javier Buesa, Vicente Monedero, Maria J. Yebra, Joana Rocha-Pereira, Roberto Gozalbo-Rovira, Jesús Rodríguez-Díaz

Institutions: Universitat de València, INCLIVA Health Research Institute, Rega Institute for Medical Research, KU Leuven, Consejo Superior de Investigaciones Científicas, Instituto de Agroquímica y Tecnología de Alimentos

Language: English

Topic: Viral gastroenteritis research and epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,790

Funders: Fonds Wetenschappelijk Onderzoek, Generalitat Valenciana, KU Leuven, Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación

OpenAlex ID: W4416821068