Pauci-immune crescentic glomerulonephritis masquerading as goodpasture syndrome: ocular clues in a young adult: a case report
Year: 2025
Type: article
Study design: Case Report
Abstract: BACKGROUND: Pauci-immune crescentic glomerulonephritis (PICGN) is a major cause of rapidly progressive renal failure and is commonly linked to ANCA-associated vasculitis. While renal and pulmonary manifestations are typical, posterior segment ocular involvement—particularly hypertensive retinopathy with exudative retinal detachment and retinoschisis—is rarely described. Reporting such cases is important, as these features may mimic other inflammatory choroidopathies and can delay appropriate diagnosis and treatment. CASE PRESENTATION: A 21-year-old previously healthy man developed blurred vision shortly after a viral illness and an NSAID injection. He progressed to malignant hypertension and renal failure requiring dialysis. Ophthalmic examination revealed bilateral hypertensive retinopathy with subretinal fluid, pigment epithelial detachments, and retinoschisis on optical coherence tomography. Renal biopsy demonstrated a pauci-immune crescentic glomerulonephritis with 14 cellular crescents and extensive global sclerosis, while immunofluorescence showed no immune complex deposition. Anti-GBM serology was negative, and subsequent testing confirmed p-ANCA (anti-MPO) positivity. The patient was treated with corticosteroids and later initiated on mycophenolate mofetil after exclusion of latent infections. His visual status remained stable on follow-up. CONCLUSIONS: This case underscores that severe ocular findings in young adults, particularly when accompanied by malignant hypertension, may signal underlying systemic vasculitis rather than isolated hypertensive damage. Early recognition of atypical retinal features and timely renal biopsy are essential to distinguish PICGN from Goodpasture syndrome and other immune-mediated renal diseases. Awareness of these unusual ocular manifestations may facilitate earlier diagnosis and improve clinical outcomes.
Source: BMC Ophthalmology
Authors: Aseel Faroun, Salam Iriqat, Batoul Abu Gharbia, Hamzeh Abu al Hasan
Institutions: Al-Quds University, An-Najah National University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,990
OpenAlex ID: W4416821152