Synthesis and Application of Chitosan‐Salicylic Acid Magnetic Nanoparticles in Colon Cancer Cells
Year: 2025
Type: article
Abstract: ABSTRACT In this study, magnetic nanoparticles (Fe 3 O 4 @CS‐SAL) were synthesized using chitosan as a stabilizer and conjugated with salicylic acid. The nanoparticles were characterized by powder x‐ray diffraction (PXRD), field emission electron microscopy (FESEM), and transmission electron microscopy (TEM). PXRD analysis determined a grain size of approximately 19 nm, while FESEM and TEM confirmed their spherical morphology with a mean diameter of ∼100 nm and a narrow size distribution. The cytotoxicity of Fe 3 O 4 @CS‐SAL was evaluated against colon cancer cells (C26), demonstrating significant toxic effects. Additionally, their antioxidant activity was assessed via the DPPH assay, yielding an IC 50 of approximately 62.5 µg/mL.
Source: Nano Select
DOI: 10.1002/nano.70086
Authors: Aida Ebadi, Mahla Mohammadi, Mohammad Mehdi Ebadi, Sarah Mousavi, Mohammad Mashreghi, Ali Es‐Haghi, Mohammad Ehsan Taghavizadeh Yazdi, Hossein Behmadi, Mohammad Qandalee, Carlos J. Durán‐Valle, Ignacio M. López‐Coca
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,660
OpenAlex ID: W4416821161