Work

Phytochemical composition and pharmacological activities of centranthera grandiflora benth.: A brief review

Year: 2025

Type: article

Abstract: • Comprehensively classification the predominant compound classes identified to date. • In-depth examination the research progress on the chemical composition and pharmacological effects. • Thorough synthesis of their structural characteristics and potential bioactivities. Centranthera grandiflora Benth. ( C. grandiflora Benth.) (大花胡麻草) is an important medicinal plant with edible varieties. It is widely used as a folk Chinese medicine in Honghe Prefecture, Yunnan Province, known for its effects in reducing swelling, dissipating stasis, promoting blood circulation, and alleviating pain. It is often used to treat injuries, high fever in children and irregular menstruation. This paper reviews the research progress on the chemical constituents and pharmacological effects of C. grandiflora Benth. to provide a basis for further research and development of its medicinal value. The relevant reports of chemical composition and pharmacological effects of C. grandiflora Benth. were collected from various academic databases and search engines, including Google Scholar, PubMed, CNKI, Wanfang and CQVIP. This study reviewed the chemical composition and pharmacological activities of C. grandiflora Benth. in vitro and in vivo studies indicate that C. grandiflora Benth. and its major bioactive constituents (iridoid glycosides) exhibit diverse pharmacological properties, including anti-myocardial ischemia, anticoagulant, anti-inflammatory, antioxidant, anticancer, antimicrobial, and hepatoprotective effects. Therefore, to facilitate the exploration and utilization of C. grandiflora Benth. resources, comprehensive investigations into the chemical composition and pharmacological properties of its remaining constituents are essential. This includes elucidating structure-activity relationships and mechanisms of action for its diverse constituents, thereby facilitating clinical applications and enhancing therapeutic efficacy.

Source: Pharmacological Research - Modern Chinese Medicine

DOI: 10.1016/j.prmcm.2025.100727

Authors: Sina Cun, Xin Li, Zhenjuan Duan, Kezhen Qi, Xiaoyun Pu

Institution: Dali University

Language: English

Topic: Phytochemistry and Biological Activities

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,550