Year: 2025
Type: article
Abstract: Lead acetate (PbAc) is an environmental toxin known to induce cardiotoxicity via oxidative stress, inflammation, and apoptosis. This study examined the protective role of borage oil (BO) in PbAc-exposed rats. Five groups were studied: Control, PbAc, PbAc + BO-50, PbAc + BO-100, and BO. Oxidative stress markers (malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT)), inflammatory cytokines (tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and nuclear factor kappa B (NF-κB)), and apoptotic genes (B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and Caspase-3) were evaluated using ELISA, real-time PCR, and Western blot. PbAc exposure significantly increased MDA levels (p
Source: Van veterinary journal
Institution: Atatürk University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4416822548