Work

A retrospective cohort study evaluating the growth and clinical outcomes of preterm and term infants with cystic fibrosis during the first 11 years of life

Year: 2025

Type: article

Abstract: Objectives: Infants with cystic fibrosis (iwCF) have lower birth weights than others. That influences nutritional and pulmonary outcomes. It was reported that 86.0% of iwCF were born full-term and 14.0% preterm. Data on the role of gestational age in growth and clinical outcomes of people with cystic fibrosis (pwCF) is limited. Objectives of this study are to assess the impact of gestational age on the growth and clinical outcomes of pwCF at 2 and 11 years of age and pulmonary function at 6 and 11 years of age. Methods: This is a retrospective, single-center, cross-sectional study, conducted between 2008 and 2024, for pwCF at Michigan Medicine. Results: A total of 170 pwCF were enrolled, 21 were premature, and 149 were full term. There was no statistical significance between the two groups in hospitalization rate, pancreatic enzyme replacement therapy, Dornase alfa use, Pseudomonas aeruginosa colonization, and cystic fibrosis transmembrane conductance regulator modulators use. There was a statistically significant difference in Vitamin K supplement, Ursodiol, and proton pump inhibitors use, with all used more in the premature group. There was no statistical significance of weight for length (WFL) at birth. At 2 years of age, there was a statistically significant difference in WFL and in body mass index between the two groups at 11 years of age. Conclusion: = 0.04). We found no difference between the groups with respect to pulmonary function testing, medication, and nutrition supplementation use.

Source: JPGN Reports

DOI: 10.1002/jpr3.70124

Authors: Hebah Reda, Sanjidah Ahmed, Julie Sturza, Samya Z. Nasr

Institutions: University of Michigan, Michigan Medicine

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,900