Work

History of glucagon-like peptide-1 receptor agonists

Year: 2025

Type: article

Abstract: • GLP-1RA development traces a century of translational progress from gut hormones to multi-agonist therapeutics. • Rational protein engineering and delivery innovations transformed incretin biology into global metabolic therapeutics. • Modern dual and triple agonists achieve surgical-level metabolic benefits, redefining diabetes and obesity care.

Source: Pharmacological Research

DOI: 10.1016/j.phrs.2025.108045

Authors: Radwan Darwish, Ghena Abu-Sharia, Alexandra E. Butler

Institutions: Royal College of Surgeons in Ireland - Bahrain, Alfaisal University

Language: English

Topic: Diabetes Treatment and Management

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,130