Mismatch Between Imaging and Histopathology Diagnosis in High and Low-Grade Gliomas: A Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Oligodendrogliomas aie diffusely infiltrating gliomas classified as WHO grade 2 or 3 tumors. While typically presenting with chronic seizures, they may rarely demonstrate imaging features suggestive of high-grade malignancy. A 40-year-old lady with untreated seizures for one year presented with acute loss of consciousness and recurrent generalized tonic-clonic seizures. Neuroimaging (CT/MRI) revealed a left temporoparietal lesion with cystic changes and hemorrhage, suggesting high-grade glioma. Histopathological analysis following craniotomy unexpectedly demonstrated WHO Grade 2 oligodendroglioma. This case highlights significant radiologic-histopathologic discordance in glioma diagnosis, emphasizing that radiologic features of high-grade malignancy may occur in low-grade oligodendrogliomas. Tissue diagnosis with molecular profiling remains essential for accurate classification and management.
Authors: Pukar Adhikari, Jabir Ahamad Miya, Shishir Bhandari, Ganesh Adhikari, Ajit Shrestha, Nikesh Tiwari
Institution: Chitwan Medical College
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416829929
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