Diagnostic Value of Signal Peptide-CUB-EGF Domain-Containing Protein 1 (SCUBE-1), Intestinal Fatty Acid Binding Protein (iFABP), and Ischemia-Modified Albumin (IMA) in Mechanical Bowel Obstruction
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: Mechanical bowel obstruction (MBO) is a common surgical pathology among patients presenting to the emergency department with abdominal pain worldwide and is associated with high morbidity rates. Delays in diagnosis and surgical intervention decisions can lead to severe complications such as bowel ischemia, adversely affecting patient survival rates. Therefore, reliable biomarkers are needed for the early diagnosis of MBO and in the surgical decision-making process. This study aimed to evaluate the diagnostic value of i-FABP, SCUBE-1, and IMA in predicting strangulation and bowel ischemia. Method: This prospective study was conducted at a tertiary hospital between January 2020 and January 2022. The study included 44 patients diagnosed with mechanical bowel obstruction who presented to the emergency department with abdominal pain, along with a control group of 40 healthy individuals. Patients were classified into two groups based on the need for surgical intervention: those who underwent surgery (Group B) and those who did not (Group A). Venous blood samples were collected, and the levels of i-FABP, SCUBE-1, and IMA were measured using the ELISA method. Data were analyzed using SPSS software. Results: The mean i-FABP levels were 56.4±11.5 ng/mL in Group A, 62.3±10.1 ng/mL in Group B, and 41.9±12.2 ng/mL in the control group, with a statistically significant difference observed between the groups (p
Institutions: Ordu University, Acıbadem University, Qatar University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416830994