Work

Solvent‐Assisted Efficient Syntheses of 1,3,5‐Triaryl‐1 H ‐Pyrazoles via Ring Opening and Cyclization in Chalcone Epoxides

Year: 2025

Type: article

Abstract: ABSTRACT Solvent‐assisted ring opening and subsequent cyclization of chalcone epoxides with hydrazine derivatives is reported under mild reaction conditions. Various 1,3,5‐triaryl‐1 H ‐pyrazole derivatives were synthesized in good to excellent product yields with functional groups tolerance. The reaction was also performed for the gram scale transformation in excellent product yield (84%). The structure was confirmed by 1 H & 13 CNMR, IR, HRMS, and SC‐XRD analysis.

Source: ChemistrySelect

DOI: 10.1002/slct.202505920

Authors: Avijit Bhakta, Naseem Ahmed

Institution: Indian Institute of Technology Roorkee

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Indian Institute of Technology Roorkee, Ministry of Education, India

Award: G3305943093