Work

Solvent‐Controlled Selective Selenylation and Sulfonylation of 1,7‐Dienes With Selenosulfonates for Divergent Synthesis of Seleno‐/Sulfonyl‐Benzoxepines

Year: 2025

Type: article

Abstract: A metal-free selective selenylation and sulfonylation of 1,7-dienes with selenosulfonates for divergent synthesis of seleno-/sulfonyl-benzoxepines has been developed. This reaction was conducted under mild conditions without any catalysts, oxidants, or additives. The choice of solvent plays a crucial role in determining the formation of seleno-/sulfonyl-benzoxepines. Preliminary mechanistic studies suggest that both the selenylation and sulfonylation are accomplished through a selenyl radical and a sulfonyl radical cyclization process.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202500919

Authors: Xiang Gao, Xiaowei Zhao, Wanqing Zhao, Anxu Pan, Man Zhang, Nengneng Zhou

Institution: Anhui Normal University

Language: English

Topic: Organoselenium and organotellurium chemistry

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

Funder: National Natural Science Foundation of China

Award: G3226506211