Work

Synthesis, Characterization, Cyclic Voltammetry Survey, and Computational Investigation of a New Series of Organoselenium Derivatives Based on N-(4-Benzoylphenyl)-2-selenocyanatoacetamide

Year: 2025

Type: article

Abstract: This study aims to synthesize and characterize new organoselenium compounds with potential redox and biological applications. The synthesis was performed by reacting N-(4-benzoylphenyl)-2-chloroacetamide with elemental selenium and potassium cyanide in DMSO under an argon atmosphere to afford a selenocyanatoacetamide intermediate, which was further halogenated to yield selenium trihalide derivatives. Structural confirmation was achieved through FTIR, 1H-NMR, and MS. Electrochemical analysis using cyclic voltammetry revealed significant redox activity, while DFT calculations provided insight into the electronic distribution and stability of the molecules. These findings suggest that the synthesized organoselenium compounds possess promising redox characteristics, supporting their potential as antioxidants or anticancer agents.

Source: Indonesian Journal of Chemistry

DOI: 10.22146/ijc.105984

Authors: Ahmed Mohammed Ismael Alsanafi, Nuha Hussain Al-Saadawy

Institution: Thi Qar University

Language: English

Topic: Organoselenium and organotellurium chemistry

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $300

Funder: University of Thi-Qar