Nirsevimab Effectiveness Against RSV‐Related Hospitalisations in Children Under 24 Months: A Test‐Negative Case–Control Study in Portugal, 2024–2025
Year: 2025
Type: article
Study design: Observational Study
Abstract: We assessed Nirsevimab effectiveness (NE) against respiratory syncytial virus (RSV)-related hospitalisation in eligible children (< 2 years) using a test-negative case-control design within the VigiRSV network (weeks 43/2024 to 16/2025). Among 341 participants (median age: 2 months; 91.2% without known chronic condition), 137 (40.2%) tested RSV-positive. Adjusted NE against RSV-related hospitalisation was 78.5% (95%CI: 59.3-89.0). Sensitivity analyses confirmed the robustness of the results. These findings support Nirsevimab's effect in a predominantly healthy infant population and contribute to informing public health decisions for RSV immunisation.
DOI: 10.1111/irv.70186
Authors: Vânia Gaio, Camila Henriques, Miguel Lança, Rita Marques, Raquel Marques, Marta Rodrigues, Sofia Almeida, Beatriz Sousa, Margarida Freitas, Diana Amaral, Sara Ferreira, Inês Azevedo, Madalena von Hafe, Rafaela Gonçalves, Regina Viseu, Teresa Bandeira, Carolina Constant, Madalena Malato, Inês Carvalho, Jorge Rodrigues, Margarida Farinha, Teresa Nunes, Teresa Graça, Sofia Gomez, Sara Soares, João Farela Neves, Paulo Paixão, Inês Piscalho, Ana Loureiro, Cristina Freitas, José Alves, Diana Soares, Paulo Lopes, Ausenda Machado, Raquel Guiomar, Ana Paula Rodrigues, VigiRSV Group
Institutions: National Institute of Health Dr. Ricardo Jorge, Comprehensive Health Research Centre, Universidade Nova de Lisboa, Unidade Local de Saúde de Almada-Seixal, Unidade Local de Saúde do Alto Ave, Unidade Local de Saúde de São José, Hospital de São João, Unidade Local de Saúde da Arrábida, Unidade Local de Saúde Santa Maria, Unidade Local de Saúde de Viseu Dão-Lafões, Hospital Lusíadas Lisboa, Unidade Local de Saúde do Alentejo Central, Hospital da Luz, Unidade Local de Saúde do Algarve, Hospital Dr. Nélio Mendonça, Unidade Local de Saúde Gaia/Espinho
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,840
OpenAlex ID: W4416840952