The Role of Brain-Derived Neurotrophic Factor in Different Psychiatric Disorders and Neurodegenerative Diseases
Year: 2025
Type: article
Abstract: Brain-derived neurotrophic factor is a widely studied neurotrophins found throughout the mammalian central nervous system. These neurotrophins regulate numerous aspects of neuronal and oligodendroglia development and function, including axonal growth, synaptic plasticity, differentiation, proliferation, survival, and apoptosis. Brain-derived neurotrophic factors have a significant impact on neurodegenerative disorders, synaptic plasticity, and the formation and maintenance of a normal brain circuit. Precise regulation of Brain-derived neurotrophic factor concentrations, including their controlled release at the transcriptional and translational levels, is essential for the correct functioning of the central nervous system. This review provides a summary of the role of Brain-derived neurotrophic factor in various neurological and mental disorders. In addition, to its role in memory recognition by increasing neuronal proliferation and survival in the perirhinal cortex, a vital area for recognizing objects in memory.
Source: AL-Kindy College Medical Journal
DOI: 10.47723/34cyc985
Authors: Suzan Hamza, Namir I. A. Haddad, Gheyath AL Gawwam
Institution: University of Baghdad
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4416841017
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