The relationships between Life’s Crucial 9, Life’s Essential 8, and sarcopenia in older adults: multicenter case–control study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Sarcopenia, the age-related loss of muscle mass and strength, is aggravated by cardiometabolic and psychosocial burden. Life's Essential 8 (LE8) and its mental-health extension Life's Crucial 9 (LC9) quantify cardio-psycho-metabolic risk, yet their relationship with sarcopenia remains untested. Methods: = 576). Sarcopenia was adjudicated by AWGS-2019. LE8 and LC9 were derived from admission nicotine, diet, sleep, physical activity, BMI, blood pressure, glucose, non-HDL-C, and PHQ-9. Multivariable logistic regression, ROC, and re-classification analyses were performed, adjusted for age, sex, BMI, hemoglobin, albumin, smoking, and comorbidity. Results: Overall sarcopenia prevalence 11.81-14.05%. Mean LC9 was lower in sarcopenic versus non-sarcopenic participants. ROC curves showed LC9 discriminated sarcopenia better than LE8. Across low, moderate, and high categories, sarcopenia prevalence descended steeply with LC9 and modestly with LE8. Multivariable analysis confirmed both scores as independent protectors. Conclusion: LC9, a freely calculable metric integrating mental health with cardio-metabolic health, is strongly and independently associated with sarcopenia in hospitalized older adults and outperforms LE8. Routine LC9 assessment at admission may enable early identification and multimodal intervention to prevent muscle loss.
Source: Frontiers in Medicine
Authors: Hui Li, Huaqing Liu, Jialin Zhang, Hui Nie, Shunnan Wang, Zhibang Zhao, Gengze Wang
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416841175