Oral health challenges in siblings diagnosed with west syndrome: Report of rare case
Year: 2025
Type: article
Study design: Case Report
Abstract: West syndrome is a rare epileptic encephalopathy of infancy characterized by a triad of infantile spasms, hypsarrhythmia on EEG, and developmental regression. Etiologies include genetic mutations and structural brain abnormalities, and familial cases being exceptionally rare. This report describes two siblings, aged 4 and 7 years, both diagnosed with West syndrome. Both children exhibited neurological deficits, global developmental delay, intellectual disability, and frequent seizures. In addition, they presented with oral manifestations including dental attrition, dental caries, and sialorrhea (excessive salivation), likely due to neuromuscular incoordination and poor oral hygiene. Dental management was challenging due to the high frequency and limited cooperation. As invasive treatment posed significant risks, preventive care was prioritized. This included the application of topical fluoride varnish to arrest carious lesions and dietary modifications to reduce cariogenic exposure. Although general anesthesia was considered for comprehensive care, it was contraindicated due to the children’s classification as ASA Physical Status III, indicating significant systemic compromise. This case highlights the complexities of managing dental health in patients with West syndrome and underscores the importance of early, noninvasive, and multidisciplinary approaches to optimize oral and general health outcomes in neurologically compromised pediatric patients. Keywords: Dentistry, Dental care, Oral manifestations, West syndrome
Source: Clinical Dentistry
Authors: Anuja Gaikwad, Seema Bargale, Poonacha K. S., Sushil Chavan, Mrunal Borawake
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416841245