Work

First reported case of peri-ureteric urothelial carcinoma

Year: 2025

Type: article

Abstract: We report the first documented case of peri-ureteric, low-grade urothelial carcinoma presenting over two decades after initial non-muscle-invasive bladder cancer (NMIBC). A 75-year-old male, treated with intravesical BCG, remained recurrence-free for ten years before developing a low-grade bladder recurrence after ten years. Surveillance imaging revealed left hydronephrosis and peri-ureteric thickening despite normal ureteroscopy and negative cytology. CT-guided biopsy confirmed low-grade papillary urothelial carcinoma external to the ureter. Robot-assisted nephroureterectomy showed a non-invasive tumour encasing, but not invading, the ureter, suggesting origin from ectopic urothelial nests. This rare presentation highlights a surveillance blind spot for extraluminal urothelial carcinoma.

Source: Urology Case Reports

DOI: 10.1016/j.eucr.2025.103300

Authors: Mandana Gholami, Jimmy Lam

Institution: Flinders Medical Centre

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,160