Work

The Active Efficiency of a Functional Beverage Extracted From Sadab (Ruta graveolens) and Kurchi (Holarrhena antidysenterica) Against Helicobacter pylori Bacteria

Year: 2025

Type: article

Abstract: Medicinal plants represent promising sources of safe, natural agents that can complement antibiotic therapy against Helicobacter pylori. This study evaluated the antioxidant and anti-H. pylori activities of aqueous extracts from Ruta graveolens (sadab) and Holarrhena antidysenterica (kurchi) to formulate a functional beverage with good sensory acceptance. The extracts were analyzed for their phytochemical content (phenolics and flavonoids), antioxidant capacity, biological activities (antimicrobial, anti-H. pylori, antibiofilm, anti-hemolytic), cytotoxicity, and sensory quality. Sadab exhibited higher levels of phenolics and flavonoids, as well as greater antioxidant and antibacterial activity, than Kurchi. Both extracts displayed potent bactericidal action at low concentrations, suppressed H. pylori biofilm and hemolysin formation by more than 90%, and maintained cell viability above 90% in normal fibroblasts, confirming good in-vitro safety. Sensory evaluation identified the most acceptable beverage formulations at 0.50% for sadab and 0.75% for kurchi. These findings demonstrate the potential of sadab and kurchi as safe, plant-based ingredients for developing functional beverages with anti-H. pylori and antioxidant benefits, supporting further in vivo and formulation studies.

Source: Food Technology Research Journal

DOI: 10.21608/ftrj.2025.467520

Authors: Ebtehal, A. El-Kholany, Hayam, A. El-Sawy, Shaimaa, M. Hassan, Eman, S. El-Ashaal

Institution: Agricultural Research Center

Language: English

Topic: Essential Oils and Antimicrobial Activity

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416849330