Work

Hepatitis B in Ethiopia: viral load, affordability, and patient perspectives at a tertiary hospital in Addis Ababa, Ethiopia

Year: 2025

Type: article

Abstract: BACKGROUND: Hepatitis B virus (HBV) is a leading cause of liver infections, which can lead to chronic illness and, in some cases, liver cancer. It affects millions of people worldwide, with a particularly high burden in Africa, especially Ethiopia. Despite its prevalence, access to HBV viral load testing is limited, and its affordability has not been well documented, particularly in Ethiopia, making it challenging to diagnose and treat the disease effectively. Therefore, this study aimed to quantify the HBV viral load, assess affordability, knowledge, attitudes, and practices related to the disease, and identify various determinants associated with these parameters." study aimed to quantify the HBV viral load, affordability, knowledge, attitudes, and practices related to this disease among HBV-infected patients at St. Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia, in 2024. METHODS: 6800. Knowledge, attitudes, and practices (KAPs) were measured using a Likert scale. Data management and analysis were conducted using SPSS version 25, with a significance level set at p < 0.05. RESULTS: A total of 256 participants were included in this study, 53.1% of whom were females. Compared with female participants, male participants demonstrated a significantly greater likelihood of having a high viral load (AOR = 2.49, 95% CI: 1.26-4.92, p = 0.01). Individuals with co-infections exhibited a substantially increased likelihood of having a high viral load (AOR = 8.38, 95% CI: 3.76-12.29, p < 0.01). Regarding KAP concerning HBV infection, 50% of the participants demonstrated good knowledge, and 38.3% exhibited a positive attitude, and 57.8% reported good practices. Urban residents (AOR = 0.11, 95% CI: 0.02-0.60, p = 0.01), higher-income earners (AOR = 0.14, 95% CI: 0.05-0.43, p < 0.01), and individuals who had undergone viral load testing within the previous month (AOR = 0.01, 95% CI: 0.09-0.17, p < 0.03) all demonstrated significantly lower odds of experiencing catastrophic expenditures. CONCLUSION: This study highlights the importance of tailored HBV management strategies, including targeted interventions and comprehensive infection prevention and control. Enhancing public health education and reducing financial barriers to HBV diagnosis and care, especially for vulnerable populations, remain crucial. CLINICAL TRIAL NUMBER: Not applicable.

Source: BMC Infectious Diseases

DOI: 10.1186/s12879-025-12124-6

Authors: Kassalem Dessie, Regasa Diriba, Amanuel Fekadu, Yewbdar Adugna, Abay Sisay

Institutions: St. Paul's Hospital Millennium Medical College, Addis Ababa University

Language: English

Topic: Hepatitis B Virus Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: gold

Estimated APC paid: $3,090