Work

Mechanism for a molecular assembler of sequence-controlled polymers using parallel DNA and a DNA polymerase

Year: 2025

Type: article

Abstract: Construction of a molecular assembler from DNA that executes a programmed sequence of chemical reactions is a formidable challenge but worthwhile because it would allow assembly and evolution of functional polymers. We present a mechanism using parallel DNA and a DNA polymerase to address two challenges that currently block progress.

Source: Nanoscale Horizons

DOI: 10.1039/d5nh00505a

Authors: Jonathan Bath, Andrew J. Turberfield

Institution: University of Oxford

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: UK Research and Innovation, Engineering and Physical Sciences Research Council

Award: An Artificial Ribosome