A low-protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy
Year: 2025
Type: article
Abstract: Despite the beneficial impact of bariatric surgery on obesity and metabolic disease, continued post-surgical obesity and weight recurrence are common, but may be impacted by diet. While guidelines recommend a post-operative high-protein diet to preserve lean mass, emerging evidence suggests that humans and mice are metabolically healthier on low-protein diets. Here, we assess the effect of varying dietary protein on post-surgical metabolism in a mouse model of sleeve gastrectomy. We find that a low-protein diet optimally drives post-surgical weight loss, boosts energy expenditure, and improves blood glucose regulation, likely, in part, due to the induction of FGF21. Through multi-omics, we identified clusters of differentially expressed genes and metabolites that correlate with these phenotypes and find that diet heavily influences the liver's molecular response to sleeve gastrectomy. These results suggest that current post-surgical high-protein diets may limit the short- and long-term benefits of surgery and warrant human clinical trials.
Source: Cell Reports Medicine
Authors: Julia Illiano, Cara L. Green, Alina Chao, Grace Zhu, Luiz Lopez, Odin Schaepkens, Cholsoon Jang, Dudley W. Lamming, David A. Harris
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,620
Funders: Hevolution Foundation, U.S. Department of Veterans Affairs, Wisconsin Alumni Research Foundation, Glenn Foundation for Medical Research, Dalio Foundation, Medtronic, National Institutes of Health, School of Medicine and Public Health, University of Wisconsin-Madison, Diabetes Research Center, University of Washington, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, Department of Surgery, Office of the Vice Chancellor for Research, University of Illinois at Chicago, Division of Diabetes, Endocrinology, and Metabolic Diseases, Nathan Shock Center, University of Alabama at Birmingham
Awards: G117713310, G1230067360, G1821720574, G226283463, G2337220457, G2482204315, G2665618970, G3330331223, G3699617803, G3818147302, G42610423, G441436445, G4755141327, G5099818834, G5660351602, G6207920146, G635200172, G6733044160, G7509565674, G7667824514, G776830455, G7770927085, G8464745751, G8800998836, G9000025623, G9000078027, G9000114108, G9000115444, G9000355804, Integrating spatial transcriptomics and single cell RNA-sequencing to mechanistically define bariatric surgery's impact on Alzheimer's Disease
OpenAlex ID: W4416865993