Constructing the spatiotemporal atlas of single-cell lineage trajectories in stereotypic biological structures
Year: 2025
Type: article
Abstract: cell type. Through 3D mathematical modeling, SCST facilitates the spatial reconstruction of a single-cell molecular atlas and the delineation of cellular heterogeneity. When integrated with temporal data, SCST can also delineate the spatiotemporal lineage trajectory at single-cell resolution in a developing biological entity.
Source: iScience
Authors: Ran Wang, Xianfa Yang, Chengfei Lian, Jianjie Wang, Jiehui Chen, Yun Qian, Yaochen Xu, Liantang Wang, John C. Marioni, Patrick P.L. Tam, Naihe Jing
Institutions: Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, State Key Laboratory of Cell Biology, Xi'an Jiaotong University, Guangzhou Laboratory, Northwest University, European Bioinformatics Institute, University of Cambridge, Cancer Research UK, The University of Sydney, Children's Medical Research Institute
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,240
OpenAlex ID: W4416866497