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Dynamics and biodistribution of cardiomyocyte-derived small extracellular vesicles following myocardial infarction: sex differences

Year: 2025
Type: article
Abstract: Although extracellular vesicle (EV) contents and cargoes have attracted significant interest for their roles in intercellular and interorgan communication after myocardial infarction (MI), the endogenous dynamics and biogenesis of cardiac small EVs following MI, and their sexual differences, remain largely unknown. Here, we present the first in vivo characterization of cardiomyocyte-derived small EVs dynamics and sexual dimorphism in response to MI injury, establishing a framework and offering crucial mechanistic insights for future studies.
DOI: 10.1152/ajpheart.00835.2025
Authors: Xinjie Wang, Xiao Du, Zhishi Chen, Wei Yu, Zhongjing Wang, Yanping Chen, Daniel Y. Chang, Garrett Jensen, Weijia Luo, Jiang Chang
Language: English
Open Access status: hybrid
Awards: G1513918759, Epigenetic signaling, pathological cardiac hypertrophy and Western diet, G5054785612, G5851240013, Rnd3 and arterial stiffness, G9000262018, Metabolic Resuscitation in Heart Failure.
OpenAlex ID: W4416869871
FWCI: 0.255
Cites: 24
Cited by: 1
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