Work

Chrysoeriol Exerts Antiplatelet Effects by Regulating cAMP/cGMP and PI3K/MAPK Pathway

Year: 2025

Type: article

Abstract: production and secretion of dense granules (ATP and serotonin). Chrysoeriol also impaired thrombin-induced clot retraction, further suggesting its capacity to regulate platelet responses and cytoskeletal rearrangements. These findings highlight chrysoeriol's multi-target mechanisms, including modulation of cyclic nucleotides, kinase pathways, and platelet function, offering potential as a therapeutic agent to prevent thrombotic cardiovascular events.

Source: Biomolecules & Therapeutics

DOI: 10.4062/biomolther.2025.090

Authors: Ga Hee Lee, Jin Pyo Lee, Akram Abdul Wahab, Na Yoon Heo, Chang Eun Park, Dong-Ha Lee

Institutions: Namseoul University, Kyungpook National University

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Namseoul University