Exploring community and expert perceptions of the acceptability of an oropharyngeal gonorrhoea controlled human infection model in Australia
Year: 2025
Type: article
Abstract: The development of an oropharyngeal gonorrhoea controlled human infection model (CHIM) could result in important translational outcomes, including accelerated development of new drugs and vaccines. Ethical study design for such a model requires community consultation, including assessment of the acceptability of the proposed CHIM among key stakeholders. This qualitative study involved: (i) semi-structured interviews and focus groups with individuals who would be eligible for participation in the proposed oropharyngeal gonorrhoea CHIM, defined as healthy men who have sex with men (MSM) aged 18-50 years living in Victoria (Australia); and, (ii) semi-structured interviews with gonorrhoea experts. Data were analysed using inductive thematic analysis supported by NVivo. Twenty-seven semi-structured interviews and one focus group were undertaken with 32 individuals between July and November, 2024, comprising 22 potential CHIM participants, and 10 experts. Overall, an oropharyngeal gonorrhoea CHIM was acceptable to most participants. Financial compensation and including only MSM who do not have sex with women were highlighted as key areas of debate. Participants highlighted that recruitment strategies should be sensitive to the stigma associated with gonorrhoea and history of stigma experienced by MSM. An oropharyngeal gonorrhoea CHIM is acceptable to key stakeholders but must be carefully designed to avoid exacerbation of stigma.
Source: Scientific Reports
Institutions: The Royal Melbourne Hospital, The University of Melbourne, Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute, University of Oxford, The Alfred Hospital, Melbourne Sexual Health Centre, Alfred Health, Monash University, University of St Andrews, Walter and Eliza Hall Institute of Medical Research
Language: English
Topic: Ethics in Clinical Research
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: Tackling Australia’s rapidly growing burden of sexually transmitted infections (STIs) by digitally transforming STI healthcare, The Wellcome Centre for Ethics, Innovation, Globalisation and Medicine, G2979159128, Design and implementation of a human challenge model for Neisseria gonorrhoeae, Translational studies in infectious diseases, Optimising the control and management of sexually transmitted infections through research and innovation, G4709323824, A collaborative platform and network for responsive infectious diseases bioethics research, Applying pathogen genomics to the prevention and control of antimicrobial resistance, A new model for improved syphilis management and control
OpenAlex ID: W4416892777