Work

Association Between Nephrolithiasis and the Prevalence of Sarcopenia in Chinese Older Adults: A Cross-Sectional Study Using Propensity Score Matching

Year: 2025

Type: article

Abstract: Background: Sarcopenia is an age-related condition characterized by loss of muscle mass and function. Nephrolithiasis represents a prevalent urological disorder that imposes a substantial burden on healthcare resources. However, the association between sarcopenia and nephrolithiasis remains poorly characterized. Methods: A total of 2586 older adults were included in this cross-sectional study. We used the univariate and multivariate logistic regression models to assess the relationship between nephrolithiasis and sarcopenia. Additionally, stratified analyses and propensity score matching (PSM) were performed to account for potential confounding factors. Results: The prevalence of sarcopenia in the present study was 7.2%. In Model 4, which integrated for all relevant covariates, nephrolithiasis was associated with approximately a 190% increased prevalence of sarcopenia compared to non-nephrolithiasis patients (OR: 2.912, 95% CI: 1.708– 4.968, P < 0.001). Following PSM, the results also confirmed the association between nephrolithiasis and sarcopenia (OR: 4.426, 95% CI: 1.547– 12.661, P = 0.006). Notably, this association was more pronounced in subgroups including males (OR: 3.296, 95% CI: 1.436– 7.564, P = 0.005), lower education level (OR: 8.127, 95% CI: 3.057– 21.609, P < 0.001), and diabetes (OR: 6.686, 95% CI: 2.626– 17.027, P < 0.001). Conclusion: Our findings demonstrate that nephrolithiasis is positively related to the potential risk of sarcopenia in Chinese older adults. This finding indicates that nephrolithiasis may contribute to sarcopenia development, thereby emphasizing that prevention and intervention strategies for sarcopenia should account for the adverse effects of nephrolithiasis. Keywords: cross-sectional study, nephrolithiasis, older adults, propensity score matching, sarcopenia

Source: Clinical Interventions in Aging

DOI: 10.2147/cia.s547830

Authors: Cheng Wu, Xiao-Qing Li, Shan-Shan Lu, Zheng-Kai Shen, Xiang Lu

Institutions: Nanjing Medical University, Jiangsu Provincial Center for Disease Control and Prevention

Language: English

Topic: Nutrition and Health in Aging

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836