Work

Synthesis and separation of two stereoisomers of deuterated tetrasubstituted allylic alcohols via consecutive dual 1,2-metallate shifts

Year: 2025

Type: article

Abstract: consecutive dual 1,2-metallate shifts, achieving efficient construction of both isomeric deuterated allylic alcohols without the requirement for condition optimization or the selection of special reagents and substrates upon oxidation. And the method features quantitative deuterium incorporation (>99%), broad substrate scope, and direct access to pharmaceutically relevant scaffolds under mild conditions.

Source: Chemical Science

DOI: 10.1039/d5sc06886j

Authors: Puhui Li, Yajun Yu, Xingxing Ma, Qiuling Song

Institutions: Fuzhou University, Hubei Normal University, Henan Normal University, Nanjing University

Language: English

Topic: Chemical Reactions and Isotopes

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: diamond

Funders: Henan Normal University, National Natural Science Foundation of China, Nanjing University, State Key Laboratory of Coordination Chemistry

Awards: G2470366598, G3990273756