Work

Modelling Neural Disorders with the D. melanogaster Larval Peripheral and Adult Dopaminergic Systems

Year: 2025

Type: article

Abstract: The increasing prevalence of neurological disorders highlights the need for disease animal models to elucidate the underlying biomolecular and cellular mechanisms of disease and to facilitate studies aimed at developing effective treatments. The fruit fly Drosophila melanogaster, at both larval and adult stages, can serve as an effective model for different human-relevant neurological diseases. Larvae are particularly suited for studying peripheral nervous system disorders, such as Charcot–Marie–Tooth and amyotrophic lateral sclerosis, while adults enable investigations of higher-order cognitive functions and age-related conditions, including Parkinson’s disease and depression-like behaviours. Combining larval and adult models offers a complementary framework to dissect the biomolecular pathways of neurological disorders and accelerate preclinical research.

Source: Biomolecules

DOI: 10.3390/biom15121677

Authors: Daniel Tendero-Lopez, Maria Dominguez, Mario Aguilar-Aragon

Institutions: Universitat de Miguel Hernández d'Elx, Consejo Superior de Investigaciones Científicas, Instituto de Neurociencias

Language: English

Topic: Neurobiology and Insect Physiology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258