Work

Novel ultrastructural insights in lung surfactant membrane complexes under closer-to-native conditions as revealed by cryo-microscopy techniques

Year: 2025

Type: article

Abstract: We have applied some of the most advanced methodologies in cryo-electron microscopy and X-ray tomography to the characterization of native pulmonary surfactant. We still do not understand the way lung surfactant membranes unravel, once secreted, at the respiratory air-liquid interface, and current models are still based on structural observations made when the methodologies available 30 years ago required extensive manipulation/perturbation of membrane materials. Our study reveals new features on the architecture of this system.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00241.2025

Authors: Francisco Javier Chichón, Alejandro Cerrada, Rocío Arranz, Antonio Cruz, José María Valpuesta, Jesús Pérez-Gil

Institutions: Consejo Superior de Investigaciones Científicas, Centro Nacional de Biotecnología, Universidad Complutense de Madrid, Research Institute Hospital 12 de Octubre

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funders: Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación, Centro Nacional de Biotecnología

OpenAlex ID: W4416909565

FWCI:

Cites: 60

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