Niclosamide suppresses gastric cancer progression through YTHDF2 inhibition-affected lactate metabolic reprogramming
Year: 2025
Type: article
Abstract: . Niclosamide disrupted metabolic reprogramming and lactate dynamics within the tumor microenvironment. YTHDF2 emerged as a critical modulator of GC metabolism, with niclosamide suppressing tumors through the YTHDF2-mediated regulation of metabolic genes. Our research revealed comprehensive metabolic alterations in gastric cancer, including upregulated lactate metabolism that promotes tumorigenesis via the lactate shuttle. Niclosamide targets the m6A methylation regulatory protein YTHDF2, which influences genes related to metabolism, indicating its potential as a prospective treatment for GC.
Source: iScience
Authors: Mosheng Tang, Yiyin Hu, Xiaohui Zhu, Jichen Dai, Rui Li, Xinran Feng, Kangrui Chi, Xinyi Li, Qiaofei Zhang, Ke Chen, Ruoying Cao, Hanqing Zhu, Haoran Huang, Haipeng Wu, Lejia Sun, Tongke Chen, Jun Wu, Huafu Wang, Zhihong Gui
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,240
Awards: G5623792973, G5888956356
OpenAlex ID: W4416910300