Work

Primary Basal Cell Adenoma of the Lacrimal Gland: A Rare Case

Year: 2025

Type: article

Abstract: Introduction: Basal cell adenoma (BCA) is a rare benign tumor of the salivary gland, reported to account for 1-3% of all salivary gland tumors, and is the third most common benign salivary gland tumor after pleomorphic adenoma (PA) and Warthin's tumor. We present the first case of a primary BCA of the lacrimal gland, an extremely rare condition, which is very similar in clinical presentation to PA of the lacrimal gland tumor. Case Presentation: An 18-year-old male patient experienced mild right proptosis for 3 years, without diplopia or pain. Orbital CT showed partial bone erosion, and MRI showed a 16 × 18 × 25 mm lobulated, well-defined mass. Anterior orbitotomy was performed to totally remove the entire lacrimal gland tumor along with its surrounding periosteum. Histopathological exams revealed a biphasic pattern of solid and cribriform, with no evidence of perineural invasion, vascular invasion, or invasion of surrounding tissues. The cell membrane and many nuclei of the tumor cells were positive for β-catenin. Conclusion: BCA is a very rare tumor of the lacrimal gland, but complete resection is the effective treatment. Postoperative follow-up is necessary due to the possibility of malignant transformation.

Source: Case Reports in Ophthalmology

DOI: 10.1159/000548364

Authors: Tokuhide Oyama, Makoto Miyajima, Ayako Tazawa

Institutions: Nagaoka Red Cross Hospital, Niigata University

Language: English

Topic: Ocular Oncology and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,030