Comprehensive analysis of multiple species identifies novel molecular signatures and pathways involved in aging
Year: 2025
Type: article
Abstract: Aging is an important pathological basis of age-related diseases. However, the similarities and differences among different types of senescent cells of different species and their role in normal homeostasis are poorly understood. Herein, in order to comprehensively map age-related transcriptome changes in multiple tissues of vertebrates during the ageing process, we analyzed 581 samples from 54 aging transcriptome datasets spanning 4 species including Homo sapiens, Mus musculus, Rattus norvegicus and Danio rerio, and identified the novel age-related differentially expressed genes, and obtained specific enriched expression of age-related pathways. Protein-protein interactions of differentially expressed genes in different species with the PTPRC or CD45 as the core were predicted. Through this study, we screened the key biomarkers and signaling pathways that regulate the aging process of tissues and organs in multiple species, which is of great significance for improving age-related tissues and organs by identifying senescent cells. • A total of 581 samples from 54 aged transcriptome datasets were analyzed, including Homo sapiens, Mus musculus, Rattus norvegicus and Danio rerio • Compared with organs in the young stage, aging organs have both interspecies-specific and species-specific changes in gene expression • Protein-protein interactions of differentially expressed genes in different species with the protein tyrosine phosphatase receptor type C (PTPRC or CD45) as the core were predicted.
Source: Genomics
Authors: Weijuan Cai, Kunying Chong, Bo Zhou, Yanni Zhao, Binchang Lao, Liang Yin
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,980
OpenAlex ID: W4416910914