Work

Clinicopathologic and prognostic significance of TIAM2 overexpression in resected hepatocellular carcinoma

Year: 2025

Type: article

Abstract: Background The clinicopathologic and prognostic significance of T-cell lymphoma invasion and metastasis 2 (TIAM2) in hepatocellular carcinoma (HCC) remains unclear.Methods TIAM2 expression was detected immunohistochemically in matched HCC and adjacent liver (AL) specimens from 168 patients with radical resection. The correlations between TIAM2 and clinicopathologic parameters, overall and disease-free survival were evaluated. The expression, prognostic value and genomic alterations of TIAM2 gene were explored in the online publicly available databases.Results TIAM2 was significantly overexpressed in HCC tissues, compared with AL tissues (P < 0.001). Its expression in multiple tumors was also statistically higher than that in solitary ones (P = 0.017). Moreover, TIAM2 overexpression was univariately associated with poor overall and disease-free survival (P = 0.0066 and 0.0060). In multivariate Cox regression analysis, TIAM2 overexpression was one of significant determinants of both overall and disease-free survival. In the Ualcan and Kaplan-Meier Plotter databases, overexpression and prognostic power of TIAM2 gene in HCC was confirmed, while its genetic alterations included mutation, amplification and deep deletion in the cBioPortal database. Some known tumor-related genes, such as FGD6, FGFR2 and FZD1, were strongly related to TIAM2 gene.Conclusions TIAM2 overexpression closely correlated with tumor multiplicity and poor prognosis in resected HCC, thus being a potential therapeutic target.

Source: Future Science OA

DOI: 10.1080/20565623.2025.2582439