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The Association Between Varicella and Acute Appendicitis: A Rare Case Report and Literature Review

Year: 2025

Type: article

Abstract: Varicella-zoster virus, the causative agent of chickenpox, is typically a self-limiting disease. However, in rare cases, it has been associated with atypical complications. Here, we report a unique case of acute appendicitis following varicella infection in an otherwise healthy individual. The possible mechanisms linking varicella to appendiceal inflammation remain unclear, but viral-induced immune dysregulation and secondary bacterial infection have been suggested. In our study, we aim to highlight this rare association, discuss potential pathophysiological mechanisms, and review the existing literature on similar cases.

Source: Case Reports in Clinical Practice

DOI: 10.18502/crcp.v10i3.20308

Authors: Mahya Sadat Mohammadi, Golnaz Ghazizadeh Esslami, Amir Hossein Dehghan, Matineh Sadat Tabatabaei

Institutions: Children's Medical Center, Tehran University of Medical Sciences

Language: English

Topic: Appendicitis Diagnosis and Management

Subfield: Emergency Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416913709

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