Work

The reproductive toxicity of aggregation-induced emission nanoparticles on mouse ovarian function

Year: 2025

Type: article

Abstract: , high concentrations induced ovarian cell apoptosis, suppressed estrogen receptor (ERα and ERβ) expression, and disrupted anti-Müllerian hormone secretion, ultimately impairing reproductive function. These findings provide critical insights into the reproductive toxicity of AIEgens and establish a foundation for further mechanistic investigations to ensure their safe application in the biomedical field.

Source: iScience

DOI: 10.1016/j.isci.2025.114312

Authors: Yibin Zhang, Nan Qiao, Yihang Jiang, Miaozhuang Fan, Wenguang Zhang, Yue Jiao, Zhengzheng Li, Gang Feng, Wing-Cheung Law, Zhourui Xu, Gaixia Xu

Institutions: Hong Kong Polytechnic University, Shenzhen University

Language: English

Topic: Luminescence and Fluorescent Materials

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, Shenzhen University, Shenzhen Research Foundation

Awards: G232267631, G2831396054, G3710308315, G4363613047, G4521799402, G7691985239, G7735590376

OpenAlex ID: W4416917990

FWCI:

Cites: 50

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